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Anti -Rb2 p130 Rabbit pAb
價格：
在線咨詢
貨號：
KT011843
產(chǎn)品規(guī)格：
100 μL
Applications：
IHC/IF
Species：
M,R
購買數(shù)量：
產(chǎn)品詳情
操作說明
注意事項
Product Information
|
Description |
Rb2 p130 rabbit polyclonal antibody |
|
Protein full name |
Retinoblastoma-like protein 2 |
|
Synonyms |
130 kDa retinoblastoma-associated protein, p130, Retinoblastoma-related protein 2, RBR-2, pRb2, Rbl2 |
|
Immunogen |
Recombinant protein corresponding to Mouse Rb2 p130 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus? |
|
Uniprot ID |
Q64700, O55081 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
IHC/IF |
Mouse, Rat |
1: 500-1: 1500 |
brain, testis |
Background
RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation. RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression. It controls histone H4 'Lys20' trimethylation. It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.
Images
|
|
Immunofluorescence of paraffin embedded mouse brain using kb12 (GB111770) at dilution of 1:700 (300x lens) |
|
|
Immunofluorescence of paraffin embedded rat testis using kb12 (GB111770) at dilution of 1:700 (260x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號合肥國家大學(xué)科技園A401室